GIT2 and PAK3

Number of citations of the paper that reports this interaction (PubMedID 10896954)
49

Data Source:
HPRD (in vivo)

		GIT2	PAK3
Description		GIT ArfGAP 2	p21 (RAC1) activated kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Cytoplasm Endosome Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Small GTPase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Catalytic Activity	MAPK Cascade Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Axonogenesis Positive Regulation Of Fibroblast Migration Dendrite Development Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Organic Cyclic Compound Positive Regulation Of DNA Biosynthetic Process
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		48 interacting genes: ACTG1 ACTN1 ARHGEF6 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	13 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 RHOJ SNCA SYN1
Entrez ID		9815	5063
HPRD ID		09779	02142
Ensembl ID		ENSG00000139436	ENSG00000077264
Uniprot IDs		F8VXI9 F8W822 Q14161 Q68DM7 Q6FI58	B2RCU6 O75914
PDB IDs			6FD3
Enriched GO Terms of Interacting Partners?
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