TOMM20 and HAP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TOMM20	HAP1
Description		translocase of outer mitochondrial membrane 20	huntingtin associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Integral Component Of Mitochondrial Outer Membrane Mitochondria-associated Endoplasmic Reticulum Membrane	Nucleolus Mitochondrion Lysosome Early Endosome Autophagosome Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Dendrite Growth Cone Cytoplasmic Vesicle Dendritic Spine Axon Cytoplasm
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Protein-transporting ATPase Activity Mitochondrion Targeting Sequence Binding Unfolded Protein Binding	Signaling Receptor Binding Protein Binding Myosin Binding Transmembrane Transporter Binding Brain-derived Neurotrophic Factor Binding
	Biological Process	Protein Targeting To Mitochondrion Response To Muscle Activity TRNA Import Into Mitochondrion Protein Import Into Mitochondrial Matrix Response To 3,3',5-triiodo-L-thyronine	Protein Targeting Exocytosis Autophagy Chemical Synaptic Transmission Brain Development Anterograde Axonal Transport Retrograde Axonal Transport Protein Localization Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Neurogenesis Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Positive Regulation Of Neurogenesis Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Amyloid-beta Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cholesterol, total ( 20686565) Cobalt levels ( 26025379) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Serum alkaline phosphatase levels ( 33547301)	Developmental language disorder (syntactic complexity) ( 27016271) Esophageal cancer (squamous cell) ( 22960999)
Interacting Genes		19 interacting genes: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 CEP126 DHFR FBXO7 FEZ1 HAP1 HSD17B10 OTC PPHLN1 PTN SNCA TOMM22 UCP1 VDAC1	93 interacting genes: AEN ANTKMT APLP1 ATP5MF BARD1 BRD7 C1orf216 C2CD6 C7orf25 C8orf33 CBX8 CCDC113 CCDC13 CDC73 CDK18 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM50B FEZ1 GABARAPL2 GADD45G GIT1 GPRASP2 HDAC4 HGS HMOX2 HOXB5 HSPA1A HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 MSGN1 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A NOD2 NOP53 PABPC4 PCM1 PDCD7 PFDN1 PKN1 PPID PPOX PPP1R18 PRPF31 PSMD11 RER1 RHPN1 RIF1 RPS10 RPS25 SCNM1 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZFP1 ZMAT2 ZNF124 ZNF20 ZNF24 ZNF33B ZNF490 ZNF572 ZNF575 ZNF648 ZNF691 ZNF835
Entrez ID		9804	9001
HPRD ID		03507	02972
Ensembl ID		ENSG00000173726	ENSG00000173805
Uniprot IDs		A0A024R3W2 Q15388	P54257
PDB IDs		4APO
Enriched GO Terms of Interacting Partners?
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