MAML1 and SLIT3

		MAML1	SLIT3
Description		mastermind like transcriptional coactivator 1	slit guidance ligand 3
Image			No pdb structure
GO Annotations	Cellular Component	MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Nuclear Speck Intracellular Membrane-bounded Organelle	Extracellular Space Mitochondrion
	Molecular Function	Transcription Coactivator Activity Protein Binding Protein Kinase Binding Peptide Antigen Binding	Calcium Ion Binding Heparin Binding Roundabout Binding
	Biological Process	Atrioventricular Node Development Protein Phosphorylation Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Myotube Differentiation Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Atrioventricular Node Cell Development	Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Axon Guidance Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Cell Growth Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 27863252) Resting heart rate ( 24680774) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)	Atrial fibrillation ( 30061737) Bipolar disorder x sex interaction ( 34099189) Body mass index ( 31217584) Circulating leptin levels in high cardiovascular risk ( 31766143) Circulating leptin levels x sex interaction in high cardiovascular risk ( 31766143) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Gut microbiota (functional units) ( 27694959) Hallux valgus ( 32131869) Height ( 28552196 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory skin disease ( 25574825) Menarche (age at onset) ( 25231870) Non-word reading ( 30741946) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Treatment resistant depression ( 30468137)
Interacting Genes		12 interacting genes: CDK8 CREBBP EP300 HDAC9 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PIAS1 RBPJ SLIT3 TP53	11 interacting genes: CAPN1 CASP9 HRH2 IGSF8 KHDRBS3 MAML1 MAPK9 MGAT4B ROBO2 RXRB SQSTM1
Entrez ID		9794	6586
HPRD ID		05665	04775
Ensembl ID		ENSG00000161021	ENSG00000184347
Uniprot IDs		Q92585	O75094
PDB IDs		2F8X 3NBN 3V79 6SMV
Enriched GO Terms of Interacting Partners?
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