RNF144A and USP21

Number of citations of the paper that reports this interaction (PubMedID 23105109)
19

Data Source:
BioGRID (two hybrid)

		RNF144A	USP21
Description		ring finger protein 144A	ubiquitin specific peptidase 21
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Neuron Projection Development Positive Regulation Of Transcription, DNA-templated
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS		Allergic rhinitis ( 30013184) Asthma ( 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Esophageal adenocarcinoma x smoking interaction ( 29551738) Intracranial aneurysm ( 30823506) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Manic episodes in bipolar disorder ( 26297903) Response to antipsychotic treatment ( 20195266)
Interacting Genes		28 interacting genes: CYSLTR2 DGAT2L6 E2F1 E2F2 E2F3 E2F4 EGFR HSPA2 MFSD5 PAQR6 PARP1 RFT1 SEC22A SGTA SGTB SLC7A1 TMEM31 UBC UBE2D1 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32 YIF1A	61 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350
Entrez ID		9781	27005
HPRD ID		11510	05291
Ensembl ID		ENSG00000151692	ENSG00000143258
Uniprot IDs		P50876	Q9UK80
PDB IDs		1WIM 6L99	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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