PCLAF and UHRF1

Number of citations of the paper that reports this interaction (PubMedID 32144273)
18

Data Source:
BioGRID (enzymatic study)

		PCLAF	UHRF1
Description		PCNA clamp associated factor	ubiquitin like with PHD and ring finger domains 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Perinuclear Region Of Cytoplasm	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Nuclear Matrix
	Molecular Function	Chromatin Binding Protein Binding	Cis-regulatory Region Sequence-specific DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Nucleosomal Histone Binding Methylated Histone Binding Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Replication Cellular Response To DNA Damage Stimulus Centrosome Cycle Response To UV Translesion Synthesis Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Maintenance Of DNA Methylation Histone Monoubiquitination Protein Ubiquitination Histone Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Protein Autoubiquitination Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		Termination of translesion DNA synthesis	DNA methylation
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Mental health study participation (completed survey) ( 31263887) Systolic blood pressure ( 30578418) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: DNMT1 PCNA TERF1 UHRF1	27 interacting genes: DNMT3A ERCC1 ERG FANCD2 FZR1 H2AC4 H2BC3 H3-3A H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 LASP1 LIG1 MBD4 MUS81 PCLAF PCNA PRKACA TP53 UBE2D1 UBE2D3 UBE2N UHRF2
Entrez ID		9768	29128
HPRD ID		13778	06992
Ensembl ID		ENSG00000166803	ENSG00000276043
Uniprot IDs		Q15004	A0A087WVR3 Q96T88
PDB IDs		4D2G 6EHT 6GWS 6IIW	2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW 6VCS 6VED 6VYJ 6W92
Enriched GO Terms of Interacting Partners?
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