TBKBP1 and RB1CC1

Number of citations of the paper that reports this interaction (PubMedID 30853402)
75

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)

		TBKBP1	RB1CC1
Description		TBK1 binding protein 1	RB1 inducible coiled-coil 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Phagophore Assembly Site Autophagosome Membrane Lysosome Endoplasmic Reticulum Membrane Cytosol Extrinsic Component Of Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding Protein Kinase Binding Molecular Adaptor Activity
	Biological Process	I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	Autophagosome Assembly Autophagy Of Mitochondrion Liver Development Positive Regulation Of Protein Phosphorylation Autophagy Cell Cycle Heart Development Autophagy Of Peroxisome Piecemeal Microautophagy Of The Nucleus Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Reticulophagy Glycophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Macroautophagy
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187 21743469) Asthma ( 31619474) Asthma (childhood onset) ( 31036433) Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Human herpesÂ virusÂ 7 U14Â antibodyÂ levels ( 33204752) Mean corpuscular hemoglobin ( 32888494) Multiple sclerosis ( 22190364) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		6 interacting genes: AGO2 APBA3 CALCOCO2 CBX1 RB1CC1 SKAP1	33 interacting genes: AZI2 BAP1 BLID COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 TAX1BP1 TBKBP1 THRSP UBC UMPS VHL VPS45 WIF1
Entrez ID		9755	9821
HPRD ID		12239	06019
Ensembl ID		ENSG00000198933	ENSG00000023287
Uniprot IDs		A7MCY6	Q8TDY2
PDB IDs			6DCE 6GMA
Enriched GO Terms of Interacting Partners?
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