SETD1A and LBP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SETD1A	LBP
Description		SET domain containing 1A, histone lysine methyltransferase	lipopolysaccharide binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex	Extracellular Region Extracellular Space Cell Surface Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Histone Methyltransferase Activity (H3-K4 Specific)	Lipopolysaccharide Binding Signaling Receptor Binding Protein Binding Lipoteichoic Acid Binding Lipopeptide Binding
	Biological Process	Brain Development Histone H3-K4 Dimethylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Chromatin Organization	Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Macromolecule Localization Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of Cytolysis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Parkinson's disease ( 31660654) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Red blood cell count ( 32888494)	Basophil percentage of white cells ( 32888494) Blood protein levels ( 29875488) Periodontitis (DPAL) ( 24024966)
Interacting Genes		7 interacting genes: BCKDK DPY30 EP300 H3C1 H3C14 LBP TAOK2	19 interacting genes: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 CTNNBL1 FTH1 HSPB1 PRDX4 PSMA3 PYCR3 RPS21 SETD1A SMAD3 TRA2A TSC22D4
Entrez ID		9739	3929
HPRD ID		13795	07175
Ensembl ID		ENSG00000099381	ENSG00000129988
Uniprot IDs		O15047	P18428 Q8TCF0
PDB IDs		3S8S 3UVN 4EWR
Enriched GO Terms of Interacting Partners?
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