CEP57 and SH3BP5L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CEP57	SH3BP5L
Description		centrosomal protein 57	SH3 binding domain protein 5 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Golgi Apparatus Centrosome Cytosol Microtubule	Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity Gamma-tubulin Binding	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Microtubule Anchoring Protein Homooligomerization	Intracellular Signal Transduction Negative Regulation Of Protein Tyrosine Kinase Activity
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 30423114 24390342) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883)	Lead levels ( 26025379)
Interacting Genes		48 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 DISC1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OGT OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1	10 interacting genes: CEP57 EMC2 FAM161B NINL PLEKHA5 RAB11B RAB14 RAB25 SUOX YWHAG
Entrez ID		9702	80851
HPRD ID		16261	13887
Ensembl ID		ENSG00000166037	ENSG00000175137
Uniprot IDs		Q86XR8	A0A024R0T2 Q7L8J4
PDB IDs		4L0R
Enriched GO Terms of Interacting Partners?
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