NUP93 and PLA2G6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NUP93	PLA2G6
Description		nucleoporin 93	phospholipase A2 group VI
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Centrosome Cytosol Membrane Nuclear Membrane Nuclear Periphery	Extracellular Space Mitochondrion Cytosol Plasma Membrane Integral Component Of Membrane Pseudopodium Centriolar Satellite
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Lysophospholipase Activity Phospholipase A2 Activity Protein Binding Calmodulin Binding Palmitoyl-CoA Hydrolase Activity Hydrolase Activity Serine Hydrolase Activity Protein Kinase Binding Identical Protein Binding ATP-dependent Protein Binding Calcium-independent Phospholipase A2 Activity Phosphatidyl Phospholipase B Activity Myristoyl-CoA Hydrolase Activity
	Biological Process	Protein Import Into Nucleus Nuclear Envelope Organization Poly(A)+ MRNA Export From Nucleus Nuclear Pore Complex Assembly Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction	Positive Regulation Of Protein Phosphorylation Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Urinary Bladder Smooth Muscle Contraction Antibacterial Humoral Response Cardiolipin Biosynthetic Process Phosphatidylcholine Catabolic Process Response To Endoplasmic Reticulum Stress Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cardiolipin Acyl-chain Remodeling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vasodilation Positive Regulation Of Exocytosis Phosphatidylethanolamine Catabolic Process Platelet Activating Factor Metabolic Process Phosphatidic Acid Metabolic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Female Pregnancy Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Arachidonic Acid Secretion Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Ceramide Biosynthetic Process
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation	Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic
Drugs			Quinacrine
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Gambling ( 22780124) HDL cholesterol ( 20031564) HDL cholesterol levels ( 32203549 26763881) Potassium levels ( 29403010)	Apolipoprotein A1 levels ( 32203549) Body fat percentage ( 26833246) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cutaneous nevi ( 21478494 19578365) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) Mammographic density (dense area) ( 25342443) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Percent mammographic density ( 25342443) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Triglyceride levels ( 32203549 28334899 32154731) Triglycerides ( 24097068 20686565)
Interacting Genes		7 interacting genes: AP5Z1 MPPED2 NDC1 NUP205 OPCML PLA2G6 TMEM100	12 interacting genes: CACNA1I CALM1 CCDC33 CEP76 MAT2B NUP93 RCBTB2 RUSC1 SERTAD2 TRIM50 USP54 ZBTB42
Entrez ID		9688	8398
HPRD ID		14854	04675
Ensembl ID		ENSG00000102900	ENSG00000184381
Uniprot IDs		Q8N1F7	O60733
PDB IDs		5IJN 5IJO
Enriched GO Terms of Interacting Partners?
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