VGLL4 and TEAD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		VGLL4	TEAD2
Description		vestigial like family member 4	TEA domain transcription factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Intracellular Membrane-bounded Organelle TEAD-YAP Complex
	Molecular Function	Transcription Coactivator Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Factor Activity Protein Binding Disordered Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Negative Regulation Of Hippo Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cellular Protein Catabolic Process	Vasculogenesis Neural Tube Closure Embryonic Heart Tube Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Notochord Development Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Embryonic Organ Development Negative Regulation Of Cell Death Protein-containing Complex Assembly Cellular Response To Retinoic Acid Regulation Of Stem Cell Differentiation
Pathways			YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases
GWAS		Anorexia nervosa ( 21079607) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Chronic obstructive pulmonary disease ( 30804561) Clopidogrel active metabolite levels ( 28207573) Height ( 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Moderate-to-late spontaneous preterm birth ( 31194736) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Relative hand skill in reading disability ( 24068947) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		11 interacting genes: CDK6 DAPK1 LRRK1 LRRK2 MEF2A MEF2C MFHAS1 TEAD1 TEAD2 TEAD3 TERF2IP	45 interacting genes: AKT1 ARNT AURKA BCL2L15 BECN1 C14orf39 CCND2 CDK4 CDK6 CDKN2A CDKN2B DACH1 EPHA2 FGFR4 FZR1 GLIS1 GLIS2 GNG13 HGF HIF1A INPP5A LATS2 MAP2K3 MAP2K5 MAP3K5 MYC NCOA1 NEDD4 NFIC NSD3 RAF1 RASSF1 RUNX1 SAA2 SOX3 STK11 TERT TP53 TRIM3 USF2 VGLL1 VGLL3 VGLL4 WWTR1 YAP1
Entrez ID		9686	8463
HPRD ID		11672	03432
Ensembl ID		ENSG00000144560	ENSG00000074219
Uniprot IDs		A0A075B6E4 A0A0A6YYI5 G5E9M7 G5E9M9 Q14135	A0A024QZE2 Q15562
PDB IDs			3L15 5DQ8 5DQE 5EMV 5HGU 6CDY 6E5G 6S60 6S64 6S66 6S69 6S6J 6UYB 6UYC 6VAH
Enriched GO Terms of Interacting Partners?
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