CD48 and CD2

Number of citations of the paper that reports this interaction (PubMedID 12356317)
5

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		CD48	CD2
Description		CD48 molecule	CD2 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft Extracellular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane
	Molecular Function	Antigen Binding Protein Binding Signaling Receptor Activity	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association
	Biological Process	Regulation Of Adaptive Immune Response Defense Response T Cell Activation	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Cell-cell Adhesion
Pathways		Cell surface interactions at the vascular wall	Cell surface interactions at the vascular wall
Drugs			Alefacept Siplizumab
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		20 interacting genes: ACKR1 BRIX1 C1orf68 CD2 CD244 CD247 DIO1 E2F2 EEF1D EFNA1 EFNA3 FYN GNAI3 IL18R1 IL18RAP LCK LY9 MAST2 OAZ3 P4HA1	23 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC RBM15 RHOC SH3KBP1 SP1 UBC
Entrez ID		962	914
HPRD ID		00177	01750
Ensembl ID		ENSG00000117091	ENSG00000116824
Uniprot IDs		A0A087X1S7 P09326	P06729 Q53F96
PDB IDs		2EDO	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?
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