CD40LG and IGHG1

Number of citations of the paper that reports this interaction (PubMedID 11525169)
12

Data Source:
HPRD (in vitro)

		CD40LG	IGHG1
Description		CD40 ligand	immunoglobulin heavy constant gamma 1 (G1m marker)
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Region Extracellular Space External Side Of Plasma Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Blood Microparticle
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding	Antigen Binding Protein Binding Immunoglobulin Receptor Binding
	Biological Process	Regulation Of Immunoglobulin Production Inflammatory Response Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway CD40 Signaling Pathway Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Isotype Switching Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process	Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation, Classical Pathway Defense Response To Bacterium Innate Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Ruplizumab
Diseases
GWAS		CD40 ligand levels ( 25147954) Lymphocyte counts ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)	Blood protein levels ( 29875488) Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)
Interacting Genes		6 interacting genes: CD40 CD5L IGHG1 IGKC RNF128 TP53	7 interacting genes: CD40LG FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5
Entrez ID		959	3500
HPRD ID		02311	11755
Ensembl ID		ENSG00000102245	ENSG00000211896
Uniprot IDs		P29965
PDB IDs		1ALY 1I9R 3LKJ 3QD6 6BRB 6W9G
Enriched GO Terms of Interacting Partners?
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