SCAMP1 and GAD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SCAMP1	GAD2
Description		secretory carrier membrane protein 1	glutamate decarboxylase 2
Image		No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Synaptic Vesicle Membrane Trans-Golgi Network Membrane Specific Granule Membrane Zymogen Granule Membrane Recycling Endosome Membrane	Golgi Membrane Cytosol Plasma Membrane Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Protein Binding	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding
	Biological Process	Exocytosis Post-Golgi Vesicle-mediated Transport Protein Transport	Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Response To Xenobiotic Stimulus Neurotransmitter Biosynthetic Process
Pathways		Neutrophil degranulation	GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs			Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Hippocampal atrophy ( 19668339) Intraocular pressure ( 29785010) Platelet count ( 32888494) Plateletcrit ( 32888494) Triglycerides ( 26780889)	Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Lean body mass ( 28552196)
Interacting Genes		26 interacting genes: ARFIP1 ARFIP2 EGFR EPS15 GAD2 ITSN1 KRTAP13-1 MTERF3 NDRG4 PBX3 PCYT1A PTPN9 SCAMP2 SLC9A7 SNAP23 SNAP25 SPG21 SYNRG TASOR2 TBRG4 THAP4 TP53 TRAF1 TTPA UBE3A ZMIZ2	48 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BASP1 BSND CACNG1 CALM1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A GAD1 HIGD1C LDAF1 LIME1 MAL2 MAP3K8 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TNFRSF10D TSPAN33
Entrez ID		9522	2572
HPRD ID		06072	11817
Ensembl ID		ENSG00000085365	ENSG00000136750
Uniprot IDs		A0A087WXB0 B4E2V7 O15126	Q05329 Q5VZ30
PDB IDs			1ES0 2OKK
Enriched GO Terms of Interacting Partners?
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