SPTLC2 and NOTCH3

Number of citations of the paper that reports this interaction (PubMedID 25356737)
24

Data Source:
BioGRID (pull down)

		SPTLC2	NOTCH3
Description		serine palmitoyltransferase long chain base subunit 2	notch receptor 3
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Serine C-palmitoyltransferase Complex	Golgi Membrane Extracellular Region Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	Serine C-palmitoyltransferase Activity Pyridoxal Phosphate Binding	Calcium Ion Binding Protein Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding
	Biological Process	Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Sphinganine Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Adipose Tissue Development Positive Regulation Of Lipophagy	Regulation Of Transcription, DNA-templated Notch Signaling Pathway Axon Guidance Regulation Of Developmental Process
Pathways		Sphingolipid de novo biosynthesis	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs		Pyridoxal phosphate Serine
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Red cell distribution width ( 32888494)	Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)
Interacting Genes		2 interacting genes: NOTCH3 SPTLC1	54 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 HOXA1 JAG1 JAG2 KAT2B LINC00839 LTBP1 MAML1 MAML2 MAML3 MBD1 MPPED2 MTDH MYC NEDD9 NUFIP2 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SHANK3 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 UPF1 WDR25 XKR8
Entrez ID		9517	4854
HPRD ID		05755	02607
Ensembl ID		ENSG00000100596	ENSG00000074181
Uniprot IDs		A0A024R6H1 O15270	Q9UM47
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q	4ZLP 5CZV 5CZX
Enriched GO Terms of Interacting Partners?
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