SCARB1 and KRTAP5-9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		SCARB1	KRTAP5-9
Description		scavenger receptor class B member 1	keratin associated protein 5-9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Surface Endocytic Vesicle Membrane Microvillus Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytosol Keratin Filament
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Virus Receptor Activity Phosphatidylserine Binding Lipopolysaccharide Immune Receptor Activity Scavenger Receptor Activity Transporter Activity Protein Binding 1-phosphatidylinositol Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Identical Protein Binding High-density Lipoprotein Particle Receptor Activity	Protein Binding Identical Protein Binding
	Biological Process	Endothelial Cell Proliferation Androgen Biosynthetic Process Cholesterol Catabolic Process Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Storage Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Lipopolysaccharide Cholesterol Efflux High-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Vitamin Transmembrane Transport Wound Healing Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Recognition Of Apoptotic Cell Reverse Cholesterol Transport Adhesion Of Symbiont To Host Viral Entry Into Host Cell Regulation Of Phagocytosis Intestinal Absorption Positive Regulation Of Nitric-oxide Synthase Activity Triglyceride Homeostasis Cholesterol Import	Epidermis Development
Pathways			Keratinization
Drugs		Phosphatidyl serine
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817 31217584) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) LDL cholesterol levels ( 32203549) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302 20442857) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels (lipoprotein measures) ( 27005778) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myocardial infarction ( 33532862) Renal cell carcinoma ( 21131975) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Serum metabolite levels ( 33031748) Total bilirubin levels ( 29403010) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Vitamin E levels ( 21729881) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: APOA1 APOA2 APOE CASP10 DENR GGA1 GPR35 GTF2H3 KRTAP10-9 KRTAP5-9 LTB4R2 PDZK1 PEX5 POLE PRL PXN SNAP23 SRSF9	196 interacting genes: ABHD17A ADAM12 ADAMTSL4 ADAMTSL5 ALDH3B1 ALPP ATG9A BEX2 BMP7 C10orf62 C11orf87 CATSPER1 CHIC2 CHRD CHRNG CKS1B CNNM3 COL8A1 COMT CRCT1 CREB5 CRH CRY2 CTNNBIP1 CTSZ CXCL16 CYSRT1 DCDC2 DHRS1 DMRT3 DNASE1L3 DOCK2 EMC7 ENKD1 ENPP7 FAH FAM124B FAM161A FAM74A4 FAM76B FLT3LG GGN GLP1R GLRX3 GNE GRN GSC2 HEY2 HHEX HLCS HOXA1 HOXB9 HPCAL1 HSD3B7 HSPD1 IGFBP6 JOSD1 KLHL38 KLK8 KPRP KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 LY6H MAPKBP1 MEOX2 MOBP MT1M NAXD NBPF19 NCLN NECTIN2 NECTIN3 NKD1 NLK NMU NOTCH2NLA NPBWR2 NPDC1 NR4A3 NTAQ1 NTM NTN4 NUFIP2 OTX1 P2RX4 P2RY6 P4HB PCSK5 PDE9A PFKL PGAP6 PGLS PHLDA1 PIN1 POM121L8P POTEB3 POU4F2 PRKAB2 PSMA1 PTPMT1 RAMP3 RASD1 RGS20 RNF111 SCARB1 SCNM1 SDC3 SDCBP SEMA3B SHFL SLC13A5 SLC15A3 SLC22A23 SLC25A10 SMCP SPATA3 SPATC1L SPG7 SPINK2 SPRY1 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TGM1 TOMM22 TRARG1 TYRO3 UBE2I UXT VWC2 WNT11 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF581 ZNF587 ZNF655 ZNF696 ZNF837
Entrez ID		949	3846
HPRD ID		03024	01008
Ensembl ID		ENSG00000073060	ENSG00000254997
Uniprot IDs		A0A024RBS4 Q8WTV0	P26371
PDB IDs
Enriched GO Terms of Interacting Partners?
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