NCR1 and CD247

Number of citations of the paper that reports this interaction (PubMedID 9625766)
197

Data Source:
HPRD (in vivo)

		NCR1	CD247
Description		natural cytotoxicity triggering receptor 1	CD247 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane SWI/SNF Complex	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Cellular Defense Response Signal Transduction Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity	Adaptive Immune Response Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			Muromonab
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 31672989 20383147 29293537 21779181)
Interacting Genes		8 interacting genes: ADAM33 APP CD247 CD59 FCER1G RHOU TMEM229B TMEM50B	38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		9437	919
HPRD ID		05167	01729
Ensembl ID		ENSG00000189430	ENSG00000198821
Uniprot IDs		A0A0A0MQZ0 A0A0A0MR94 A0A0A0MTU0 O76036	P20963
PDB IDs		1OLL 1P6F 6IAP	1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR
Enriched GO Terms of Interacting Partners?
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