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CD28 and CFLAR
CD28
CFLAR
Description
CD28 molecule
CASP8 and FADD like apoptosis regulator
Image
GO Annotations
Cellular Component
Immunological Synapse
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Protein Complex Involved In Cell Adhesion
Cytoplasm
Cytosol
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Membrane Raft
Ripoptosome
Molecular Function
Protease Binding
Protein Binding
Coreceptor Activity
Protein Kinase Binding
Identical Protein Binding
Protease Binding
Death Receptor Binding
Protein Binding
Enzyme Activator Activity
Protein-containing Complex Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Positive Regulation Of Cytokine Production
Positive Regulation Of Inflammatory Response To Antigenic Stimulus
Humoral Immune Response
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
T Cell Costimulation
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of T Cell Proliferation
T Cell Activation
Negative Regulation Of Apoptotic Process
Negative Thymic T Cell Selection
Regulatory T Cell Differentiation
Positive Regulation Of Viral Genome Replication
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Apoptotic Signaling Pathway
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Skeletal Muscle Tissue Development
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Skeletal Muscle Atrophy
Regulation Of Skeletal Muscle Satellite Cell Proliferation
Skeletal Myofibril Assembly
Cellular Response To Insulin Stimulus
Response To Testosterone
Wound Healing
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Skeletal Muscle Tissue Regeneration
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Necroptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Hypoxia
Cellular Response To Dexamethasone Stimulus
Cellular Response To Nitric Oxide
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Negative Regulation Of Myoblast Fusion
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Extracellular Matrix Organization
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Hepatocyte Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
PIP3 activates AKT signaling
Nef mediated downregulation of CD28 cell surface expression
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TRAIL signaling
Drugs
Diseases
GWAS
Alopecia areata (
25608926
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
20190752
25920553
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Graves' disease (
21841780
)
Heschl's gyrus morphology (
25130324
)
Inflammatory bowel disease (
26192919
)
Lymphocyte counts (
32888494
)
Multiple sclerosis (
31604244
24076602
)
Primary biliary cholangitis (
28425483
)
Primary sclerosing cholangitis (
23603763
27992413
)
Rheumatoid arthritis (
30423114
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Subcutaneous adipose tissue (
29178545
)
Systemic lupus erythematosus (
28714469
)
Ulcerative colitis (
26192919
)
Rheumatoid arthritis (
30423114
24390342
)
Triptolide cytotoxicity (
26121980
)
Interacting Genes
25 interacting genes:
AP1M1
BCS1L
CAND1
CD247
CD4
CD80
CD86
CFLAR
CTLA4
DUSP14
GRAP2
GRB2
IL12A
ITK
LCK
LRRC23
NSF
PIK3CG
PIK3R1
PIK3R2
PLCG1
PTPRC
SEC14L2
WBP2NL
YAP1
44 interacting genes:
ATF2
BCL2L1
CAB39
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CD28
CRYGA
CUL1
DAXX
DEDD
DEDD2
ECE1
EEF1B2
FADD
FGF13
FZD5
GAPDHS
GJA1
IKBKB
KCNIP3
MAP2K4
MAP2K7
MYL1
NDUFS1
NFKB1
PROC
PSEN2
QPCT
RAF1
RBX1
RIPK1
RIPK2
SKP1
SKP2
SMAD3
SPATS1
TNFRSF10B
TRAF1
TRAF2
USP8
Entrez ID
940
8837
HPRD ID
01727
04671
Ensembl ID
ENSG00000178562
ENSG00000003402
Uniprot IDs
B4E0L1
P10747
A0A024R3Y3
A0A024R3Y4
A0A336TY74
B4E361
E9PAP3
O15519
Q59F61
PDB IDs
1YJD
3WA4
5AUL
5GJH
5GJI
6O8D
2N5R
3H11
3H13
Enriched GO Terms of Interacting Partners
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