LIPG and EXOSC5

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)

		LIPG	EXOSC5
Description		lipase G, endothelial type	exosome component 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Golgi Apparatus Cell Surface	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Heparin Binding Phospholipase A1 Activity Lipase Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Biosynthetic Process Response To Nutrient Cell Population Proliferation Phospholipid Catabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Lipid Catabolic Process Triglyceride Catabolic Process Positive Regulation Of Cholesterol Transport High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis Reverse Cholesterol Transport Regulation Of Lipoprotein Metabolic Process Phospholipid Homeostasis	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		HDL remodeling	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Apolipoprotein A1 levels ( 32203549 29084231) Blood metabolite levels ( 24816252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol ester levels in very large HDL ( 29084231) Cholesterol, total ( 24097068 19060911 25961943 20686565) Coronary artery disease ( 29212778) Free cholesterol levels in medium HDL ( 29084231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 24097068 20031538 31170924 28270201 24507774 18193043 18193044 20864672 19060906 19060911 30275531 25961943 20686565 26582766) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29403010 33339817 31217584) Large HDL particle concentration ( 29084231) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219 19936222) Low density lipoprotein cholesterol levels ( 32154731) Mean diameter of HDL particles ( 29084231) Mean spheric corpuscular volume ( 32888494) Medium HDL particle concentration ( 29084231) Metabolic syndrome ( 31589552) Metabolite levels (lipoprotein measures) ( 27005778) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors in depression ( 27622933) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Testicular germ cell tumor ( 23666239) Total cholesterol levels ( 28334899 29403010 33339817 30275531) Total cholesterol levels in HDL ( 29084231) Total cholesterol levels in large HDL ( 29084231)
Interacting Genes		3 interacting genes: EXOSC5 FANCA TCF4	83 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HAMP HOXC4 IKZF3 KCTD13 KIAA1217 KMT2A KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PAF1 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PRODH2 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792
Entrez ID		9388	56915
HPRD ID		04730	16222
Ensembl ID		ENSG00000101670	ENSG00000077348
Uniprot IDs		A0A024R2B5 B4DTR8 Q9Y5X9	Q9NQT4
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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