SLC9A3R1 and P2RY1

Number of citations of the paper that reports this interaction (PubMedID 9671706)
105

Data Source:
HPRD (in vitro)

		SLC9A3R1	P2RY1
Description		SLC9A3 regulator 1	purinergic receptor P2Y1
Image
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Tip Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Postsynaptic Density Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Cell Body Postsynaptic Membrane Glutamatergic Synapse Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Protein Self-association Protein-containing Complex Binding Myosin II Binding Protein N-terminus Binding Dopamine Receptor Binding Growth Factor Receptor Binding	G Protein-coupled ADP Receptor Activity Protein Binding ATP Binding A1 Adenosine Receptor Binding Signaling Receptor Activity ADP Binding G Protein-coupled Purinergic Nucleotide Receptor Activity G Protein-coupled ATP Receptor Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway CAMP-mediated Signaling Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Glutathione Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Excretion Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Golgi Localization Negative Regulation Of Protein Kinase B Signaling Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Protein Phosphorylation G Protein-coupled Adenosine Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Glial Cell Migration Regulation Of Cell Shape Response To Mechanical Stimulus Regulation Of Signaling Receptor Activity Negative Regulation Of Norepinephrine Secretion Sensory Perception Of Pain Signal Transduction Involved In Regulation Of Gene Expression Platelet Activation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Eating Behavior Positive Regulation Of Ion Transport Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Negative Regulation Of Binding Positive Regulation Of Penile Erection Positive Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To ATP Cellular Response To Purine-containing Compound Protein Localization To Plasma Membrane Relaxation Of Muscle Blood Vessel Diameter Maintenance Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways			G alpha (q) signalling events P2Y receptors ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1
Drugs			Promethazine
Diseases
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Fibrinogen ( 20031577) Lymphocyte counts ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Chronotype ( 30696823) Immune reponse to smallpox (secreted IL-2) ( 22610502) Metabolite levels ( 23823483) Serum sulfate level ( 27412988)
Interacting Genes		70 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 AXIN2 BCL10 BCL2A1 CABP1 CD300A CFTR CLCN3 CNGA2 COG1 CRABP1 CTNNB1 DLGAP4 EGFR EZR GC GFI1 GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PHLPP1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 ST6GALNAC2 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	4 interacting genes: ADORA1 JAK1 SLC9A3R1 SLC9A3R2
Entrez ID		9368	5028
HPRD ID		05406	03103
Ensembl ID		ENSG00000109062	ENSG00000169860
Uniprot IDs		O14745	P47900
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR	1Y36 4XNV 4XNW
Enriched GO Terms of Interacting Partners?
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