SLC9A3R2 and CFTR

Number of citations of the paper that reports this interaction (PubMedID 9671706)
105

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		SLC9A3R2	CFTR
Description		SLC9A3 regulator 2	CF transmembrane conductance regulator
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Exosome	Nucleus Cytoplasm Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Golgi-associated Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Protein-containing Complex Chloride Channel Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding	Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Isomerase Activity ATP Hydrolysis Activity Chloride Channel Regulator Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding ATPase-coupled Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Chaperone Binding Sec61 Translocon Complex Binding ABC-type Transporter Activity
	Biological Process	Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Cholesterol Biosynthetic Process Vesicle Docking Involved In Exocytosis Bicarbonate Transport Cholesterol Transport Response To Endoplasmic Reticulum Stress Transepithelial Water Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Sperm Capacitation Multicellular Organismal Water Homeostasis Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Positive Regulation Of Enamel Mineralization Cellular Response To CAMP Amelogenesis Positive Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity Cellular Response To Forskolin
Pathways			ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs			ATP Bumetanide Glyburide Ibuprofen Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor
Diseases
GWAS		Diastolic blood pressure ( 27841878 30578418) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Systolic blood pressure ( 27841878 30578418)	Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Glaucoma ( 30054594) Gout ( 22179738) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Type 1 diabetes ( 34012112) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		43 interacting genes: ABCC4 ACE2 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR DLGAP4 EZR IFT140 KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TRAF4 WWP2 WWTR1	30 interacting genes: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 MARCHF2 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SHMT2 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STUB1 STX1A UBE2I
Entrez ID		9351	1080
HPRD ID		05946	03883
Ensembl ID		ENSG00000065054	ENSG00000001626
Uniprot IDs		Q15599	A0A024R730 P13569
PDB IDs		2D11 2HE4 2OCS 4P0C	1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW 4WZ6 5D2D 5D3E 5D3F 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFF 5TFG 5TFI 5TFJ 5TGK 5UAK 6GJQ 6GJS 6GJU 6GK4 6GKD 6HEP 6MSM 6O1V 6O2P 6UK1
Enriched GO Terms of Interacting Partners?
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