TAOK2 and EIF3C

		TAOK2	EIF3C
Description		TAO kinase 2	eukaryotic translation initiation factor 3 subunit C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Actin Cytoskeleton Integral Component Of Membrane Axon Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Receptor Complex Dendritic Growth Cone Axonal Growth Cone	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Neuropilin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding
	Biological Process	MAPK Cascade Regulation Of Cell Growth Protein Phosphorylation Protein Targeting To Membrane Apoptotic Process Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Signaling Axonogenesis Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Focal Adhesion Assembly Neuron Projection Morphogenesis Stress-activated MAPK Cascade Basal Dendrite Morphogenesis Basal Dendrite Arborization	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Positive Regulation Of Translation Positive Regulation Of MRNA Binding
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs		Dexfosfoserine Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Metabolic syndrome ( 31589552) Schizophrenia ( 28991256 25056061 29483656 30285260) Triglyceride levels ( 32203549 32154731) Waist circumference ( 31928498)	Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Lamb consumption ( 32066663)
Interacting Genes		22 interacting genes: BCKDK CIDEB DOC2A EIF3C ELK1 KLHL12 KRTAP6-3 MAP2K3 MAP2K6 MEGF10 RCHY1 RTRAF SETD1A TLE3 TUBA1A TUBA4A TUBB TUFM USF1 ZNF267 ZNF597 ZNF646	22 interacting genes: AAGAB ALKBH4 BCKDK CALM1 DOC2A EIF1AX EIF3E EIF3G EIF3J EIF3K ERCC6 HMOX2 MAPK6 NDUFA4L2 PFDN1 PLEKHF2 RPS6KA3 SMAD9 SNIP1 TACC3 TAOK2 TRAPPC2
Entrez ID		9344	8663
HPRD ID		18147	04889
Ensembl ID		ENSG00000149930	ENSG00000184110
Uniprot IDs		Q9UL54	A0A024QYU9 Q99613
PDB IDs			3J8B 3J8C 6YBD 6YBW 6ZMW 6ZON 6ZP4 7A09
Enriched GO Terms of Interacting Partners?
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