EFTUD2 and AP2B1

Number of citations of the paper that reports this interaction (PubMedID 28515276)
22

Data Source:
BioGRID (affinity chromatography technology)

		EFTUD2	AP2B1
Description		elongation factor Tu GTP binding domain containing 2	adaptor related protein complex 2 subunit beta 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cajal Body Membrane Nuclear Speck Intracellular Membrane-bounded Organelle U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Clathrin-coated Endocytic Vesicle Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding GTPase Activity Protein Binding GTP Binding U5 SnRNA Binding	Signal Sequence Binding Protein Binding Clathrin Binding Clathrin Adaptor Activity Protein-containing Complex Binding
	Biological Process	MRNA Splicing, Via Spliceosome Response To Cocaine Cellular Response To Xenobiotic Stimulus	Kidney Development Ventricular Septum Development Intracellular Protein Transport Vesicle-mediated Transport Aorta Development Positive Regulation Of Endocytosis Clathrin Coat Assembly Coronary Vasculature Development Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Neuron Death Positive Regulation Of Protein Localization To Membrane
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Asthma ( 31619474) Craniofacial microsomia ( 26853712)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 22139419 32888494 27863252) Mean reticulocyte volume ( 32888494) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		15 interacting genes: AP2B1 ARPC3 CYFIP1 DUX4 GOLM1 GSK3B HINFP LSM8 PIN1 SF3B3 SF3B4 SNRNP200 SREK1 SUMO2 WBP4	64 interacting genes: - ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP23 ATP6V1G1 BUB1 BUB1B C2CD6 CCDC187 CLINT1 COL3A1 DHX58 DNAJC5 EFTUD2 EGFR FMNL2 GPANK1 GTF2I HIP1 HSPB1 ITSN1 KANK2 KIAA0408 KPNA2 LDLRAP1 LONRF1 LRRFIP1 MEA1 MLH1 NECAP2 NEU4 NOS2 NUP54 PIP5K1C PKP1 POM121 PSORS1C2 RAPGEF3 RIBC2 SERTAD2 SLC25A6 SLC2A8 SMAD4 SMURF1 SNAP91 TENT5C TERF2IP TEX12 TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 UBC VSIG4
Entrez ID		9343	163
HPRD ID		04869	03015
Ensembl ID		ENSG00000108883	ENSG00000006125
Uniprot IDs		B3KX19 Q15029	A0A140VJE8 P63010 Q96EL6
PDB IDs		3JCR 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6ZYM 7AAV 7ABF 7ABG 7ABI	1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7 4UQI 5M5R 6QH5 6QH6 6QH7 6URI 6YAE 6YAF 6YAH 6YAI
Enriched GO Terms of Interacting Partners?
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