COPS2 and SENP8

Number of citations of the paper that reports this interaction (PubMedID 23408908)
20

Data Source:
BioGRID (affinity chromatography technology, far western blotting)

		COPS2	SENP8
Description		COP9 signalosome subunit 2	SUMO peptidase family member, NEDD8 specific
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome	Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Inner Cell Mass Cell Proliferation Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription	Protein Deubiquitination Post-translational Protein Modification
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle	UCH proteinases Neddylation
Drugs
Diseases
GWAS		Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		40 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CSNK2A1 CUL4B CUL5 DDB1 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 OGT PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR ZNF446	15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28
Entrez ID		9318	123228
HPRD ID		05146	09784
Ensembl ID		ENSG00000166200	ENSG00000166192
Uniprot IDs		P61201 Q59EL2	A8K8D3 Q96LD8
PDB IDs		4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N	1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?
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