CD14 and ARFGAP3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CD14	ARFGAP3
Description		CD14 molecule	ADP ribosylation factor GTPase activating protein 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome	Golgi Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Lipopolysaccharide Binding Opsonin Receptor Activity Protein Binding Peptidoglycan Immune Receptor Activity Lipoteichoic Acid Binding Lipopeptide Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Heat Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor Innate Immune Response Response To Ethanol Positive Regulation Of Endocytosis Response To Electrical Stimulus Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of NIK/NF-kappaB Signaling	Intracellular Protein Transport Protein Secretion Vesicle-mediated Transport COPI Coating Of Golgi Vesicle Regulation Of Catalytic Activity
Pathways		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic CDC42 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Resting metabolic rate ( 28476931)
Interacting Genes		15 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 REEP5 TLR2 TLR3 TLR4 TNFRSF1B	8 interacting genes: APP CD14 CXCL8 LIME1 RTN4IP1 SMAD2 SYPL1 ZDHHC17
Entrez ID		929	26286
HPRD ID		01151	06444
Ensembl ID		ENSG00000170458	ENSG00000242247
Uniprot IDs		P08571	A0A024R4U0 Q9NP61
PDB IDs		4GLP	2CRW
Enriched GO Terms of Interacting Partners?
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