CD9 and ADAM2

Number of citations of the paper that reports this interaction (PubMedID 10518536)
46

Data Source:
HPRD (in vivo)

		CD9	ADAM2
Description		CD9 molecule	ADAM metallopeptidase domain 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Protein-containing Complex Extracellular Exosome Extracellular Vesicle	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Integrin Binding Protein Binding	Metalloendopeptidase Activity Integrin Binding Metallopeptidase Activity
	Biological Process	Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Brain Development Negative Regulation Of Cell Population Proliferation Glial Cell Migration Response To Water Deprivation Oligodendrocyte Development Myoblast Fusion Involved In Skeletal Muscle Regeneration Platelet Activation Paranodal Junction Assembly Receptor Internalization Sperm-egg Recognition Negative Regulation Of Cellular Component Movement Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Platelet Aggregation Regulation Of Macrophage Migration	Proteolysis Cell Adhesion Binding Of Sperm To Zona Pellucida Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization
Pathways		Platelet degranulation Acrosome Reaction and Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin	Interaction With Cumulus Cells And The Zona Pellucida
Drugs		C31G
Diseases
GWAS		Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Mean platelet volume ( 22139419 32888494 27863252) Paclitaxel-induced neuropathy ( 23776197) Platelet count ( 26805783 22139419)	Restless legs syndrome ( 29029846)
Interacting Genes		27 interacting genes: ADAM2 ADRB2 ATM CACNA1C CD19 CD36 CD38 CD53 CD59 CD63 CD81 CLN8 HBEGF IGSF8 ITGA2 ITGA3 ITGA5 ITGB1 KIT ODF4 PRKCA PTGFRN SERPINH1 SLC22A1 SLC22A2 TSPAN4 VKORC1	2 interacting genes: CD9 CLGN
Entrez ID		928	2515
HPRD ID		00880	03322
Ensembl ID		ENSG00000010278	ENSG00000104755
Uniprot IDs		A6NNI4 B4DK09 P21926	B4DWY7 Q6P2G0 Q99965
PDB IDs		6K4J 6RLR 6Z1V 6Z20
Enriched GO Terms of Interacting Partners?
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