MOB1B and STK3

Number of citations of the paper that reports this interaction (PubMedID 24255178)
195

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		MOB1B	STK3
Description		MOB kinase activator 1B	serine/threonine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Kinase Activator Activity Kinase Binding Protein Kinase Activator Activity Metal Ion Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Signal Transduction Regulation Of Protein Autophosphorylation Positive Regulation Of Kinase Activity Hippo Signaling	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Protein Tetramerization Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Signaling by Hippo	Signaling by Hippo
Drugs			Fostamatinib
Diseases
GWAS		Leukocyte telomere length ( 32109421) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Type 2 diabetes ( 32499647 30718926)	Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		6 interacting genes: APP NT5C2 STK3 TNF TNIP1 WASHC3	42 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB1B MOB3B MOB4 MPP1 OGT ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		92597	6788
HPRD ID		17582	05433
Ensembl ID		ENSG00000173542	ENSG00000104375
Uniprot IDs		B3KSH6 Q7L9L4	A0A087WZ06 A0A384MR07 Q13188
PDB IDs			3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2
Enriched GO Terms of Interacting Partners?
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