CD3E and CD79B

Number of citations of the paper that reports this interaction (PubMedID 7541024)
1

Data Source:
HPRD (in vitro, in vivo)

		CD3E	CD79B
Description		CD3e molecule	CD79b molecule
Image
GO Annotations	Cellular Component	Immunological Synapse Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Dendritic Spine Cell Body	Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane B Cell Receptor Complex Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding Protein Heterodimerization Activity	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Positive Regulation Of T Cell Anergy Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G Protein-coupled Receptor Signaling Pathway Response To Nutrient Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cerebellum Development T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Apoptotic Signaling Pathway	Adaptive Immune Response Immune Response Signal Transduction B Cell Differentiation B Cell Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling	CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Muromonab Catumaxomab	Polatuzumab vedotin
Diseases
GWAS		Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878)	Height ( 25282103) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		28 interacting genes: ADAM33 BNIP3 CD3D CD3G CD79B CSK DRD2 EPS8L1 LCK MUC15 NAT8 NCK1 NCK2 NCL PIK3R1 PKMYT1 POLR1G PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UBASH3A UNC119 ZAP70 ZFPL1	16 interacting genes: BLK CD19 CD3E CD5 CD79A FOXJ1 FYN LCK LYN PDZD11 PTK2 PTPN6 SGTA SGTB SYK ZAP70
Entrez ID		916	974
HPRD ID		08923	00922
Ensembl ID		ENSG00000198851	ENSG00000007312
Uniprot IDs		P07766	P40259
PDB IDs		1A81 1SY6 1XIW 2ROL 5QU2 6JXR	3KG5
Enriched GO Terms of Interacting Partners?
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