ACVR1B and TDGF1

Number of citations of the paper that reports this interaction (PubMedID 11909953)
47

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		ACVR1B	TDGF1
Description		activin A receptor type 1B	teratocarcinoma-derived growth factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Activin Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type I Activin-activated Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Central Nervous System Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Growth Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Development Of Primary Female Sexual Characteristics Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin	Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs		ATP Fostamatinib
Diseases
GWAS		Adenocarcinoma ( 26732429) Age-related hearing impairment ( 24939585) Granulocyte count ( 27863252) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lung cancer ( 26732429) Neutrophil count ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum CC16 levels ( 32839289) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urate levels ( 23263486)	Blood protein levels ( 29875488 28240269) Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		25 interacting genes: ACVR2B BAG6 BAMBI BMPR2 FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SHMT2 SMAD2 SMAD4 SMAD7 SNX1 SNX2 TDGF1 TGFBRAP1 TUBA1A TUBA1C	22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2
Entrez ID		91	6997
HPRD ID		03193	01757
Ensembl ID		ENSG00000135503	ENSG00000241186
Uniprot IDs		P36896	F5H1T8 P13385
PDB IDs
Enriched GO Terms of Interacting Partners?
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