USP2 and BICD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		USP2	BICD2
Description		ubiquitin specific peptidase 2	BICD cargo adaptor 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm	Nuclear Envelope Annulate Lamellae Nuclear Pore Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding	Protein Binding Cytoskeletal Anchor Activity Small GTPase Binding Dynactin Binding Dynein Light Intermediate Chain Binding Dynein Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Protein Transport Protein Localization To Organelle Protein Localization To Golgi Apparatus MRNA Transport Centrosome Localization Regulation Of Microtubule Cytoskeleton Organization Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation	COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Refractive error ( 32231278) Serum uric acid levels ( 30993211) Urate levels ( 31985003 31578528 23263486)	Haemorrhoidal disease ( 33888516) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Neutrophil count ( 32888494) Platelet count ( 32888494) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		165 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP ASPG ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BHLHB9 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CCND1 CDC34 CEP63 CEP70 CRACR2A CRACR2B CRY1 DDI1 DEPDC5 DISC1 DTX3 DUSP21 DYDC1 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 FANCD2 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GRB7 GRIPAP1 H2AC20 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PCNA PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF166 RUNDC3A S100A10 SH2B2 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBC UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1	42 interacting genes: ARHGAP45 CBR3 CCDC187 CCHCR1 DCTN1 DCTN2 DCX FAM110A FAM161A FAM161B FAM50B GSK3B HDAC4 LNX1 MFAP1 MOS NEK9 PMF1 POLDIP3 PPP1R18 PRPF18 PRPF31 RAB6A RAB6B RBM41 SNW1 TBRG4 TCEA2 TCEANC TSGA10IP USP2 UTP14C YES1 ZC2HC1C ZMAT2 ZNF417 ZNF624 ZNF648 ZNF669 ZNF670 ZSCAN12 ZSCAN23
Entrez ID		9099	23299
HPRD ID		05287	09826
Ensembl ID		ENSG00000036672	ENSG00000185963
Uniprot IDs		O75604	Q8TD16 Q96FU2
PDB IDs		2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF	6OFP 6PSE
Enriched GO Terms of Interacting Partners?
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