THAP3 and SPTBN1

Number of citations of the paper that reports this interaction (PubMedID 21866423)
2

Data Source:
BioGRID (two hybrid)

		THAP3	SPTBN1
Description		THAP domain containing 3	spectrin beta, non-erythrocytic 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleolus Cytoplasm Cytosol Plasma Membrane Spectrin Postsynaptic Density Spectrin-associated Cytoskeleton Cell Junction Axolemma Cortical Actin Cytoskeleton M Band Cuticular Plate Cell Projection Extracellular Exosome Glutamatergic Synapse
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein-containing Complex Binding Cadherin Binding Actin Filament Binding GTPase Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeleton Organization Common-partner SMAD Protein Phosphorylation Actin Cytoskeleton Organization Positive Regulation Of Interleukin-2 Production Golgi To Plasma Membrane Protein Transport Actin Filament Capping Regulation Of SMAD Protein Signal Transduction Membrane Assembly Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane
Pathways			Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs			Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Adult body size ( 32376654) Schizophrenia ( 33169155)	Basophil percentage of white cells ( 32888494) Bone mineral density (spine) ( 19079262 19801982 18445777) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 29617998 29785010 31959993 30054594 30591961) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean platelet volume ( 32888494) Myopia (pathological) ( 22685421) Neutrophil count ( 32888494) Pars triangularis volume ( 31530798) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: APP NUTF2 SPTBN1 TRIM55 TRIM63 UBL5	49 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 EIF3H EPB41 EPB41L3 GOLGA6L10 GRB2 GRIA2 HSPB1 MAPK14 MEF2C NF2 NOP53 PACSIN1 PJA1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNAPIN SNCA SPTAN1 SREBF2 STAT1 STXBP1 SUMO2 THAP3 TNIK TRAF3IP1 YWHAG ZNF251 ZNF512B
Entrez ID		90326	6711
HPRD ID		18178	01683
Ensembl ID		ENSG00000041988	ENSG00000115306
Uniprot IDs		Q8WTV1	B2ZZ89 Q01082
PDB IDs			1AA2 1BKR 3EDV
Enriched GO Terms of Interacting Partners?
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