RHBDL1 and APOD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RHBDL1	APOD
Description		rhomboid like 1	apolipoprotein D
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Lipid Transporter Activity Protein Binding Cholesterol Binding
	Biological Process	Proteolysis Signal Transduction	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Brain Development Aging Response To Xenobiotic Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration
Pathways			Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			Vitamin A Copper
Diseases
GWAS		Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	HDL cholesterol levels ( 32203549)
Interacting Genes		13 interacting genes: ABHD16A APOD C4orf3 COMT FXYD6 KRTAP10-8 KRTAP2-3 KRTAP2-4 KRTAP6-3 MFF SPTSSA TRARG1 VAC14	51 interacting genes: AIG1 APH1A APOA2 AQP9 ATP6V0B ATP6V0E1 BCL2L13 BIK CD53 CD79A CLDN7 CLEC10A CPLX4 CREB3 CREB3L1 ERGIC3 EVI2B FAM209A FFAR2 FKBP7 FPR2 GDAP1 GJA8 GORAB GPR151 GPR42 GPX8 KCNJ6 KIR2DL3 LEPR LMNA MFF MGST3 MTERF2 MTIF3 NCAPH2 PDZK1IP1 POLR2M RHBDL1 SHBG SIGLECL1 SLC10A6 SLC35C2 TEX29 TMEM237 TMEM31 TMEM45B TMEM52B TMEM79 VAPA VSIR
Entrez ID		9028	347
HPRD ID		07050	00134
Ensembl ID		ENSG00000103269	ENSG00000189058
Uniprot IDs		O75783	P05090
PDB IDs			2APD 2HZQ 2HZR
Enriched GO Terms of Interacting Partners?
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