SOCS3 and GFRA1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SOCS3	GFRA1
Description		suppressor of cytokine signaling 3	GDNF family receptor alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Phosphatidylinositol 3-kinase Complex	Multivesicular Body Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Signaling Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity
	Biological Process	Receptor Signaling Pathway Via JAK-STAT Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Cellular Response To Leukemia Inhibitory Factor	Cell Surface Receptor Signaling Pathway Nervous System Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	NCAM1 interactions RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)	Blood protein levels ( 30072576 29875488) Delirium ( 29631748) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Malaria ( 31844061) Migraine without aura ( 28952330) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)
Interacting Genes		64 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ	5 interacting genes: GDNF NCAM1 NRTN RET SOCS3
Entrez ID		9021	2674
HPRD ID		05006	03291
Ensembl ID		ENSG00000184557	ENSG00000151892
Uniprot IDs		O14543 Q6FI39	B7Z856 P56159
PDB IDs			6Q2N
Enriched GO Terms of Interacting Partners?
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