LIMD1 and NGLY1

		LIMD1	NGLY1
Description		LIM domain containing 1	N-glycanase 1
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion RISC Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Metal Ion Binding	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Osteoblast Development Regulation Of Transcription, DNA-templated Cytoskeleton Organization Regulation Of Cell Shape Phosphorylation Cell Migration P-body Assembly Gene Silencing By MiRNA Negative Regulation Of Hippo Signaling Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Gene Silencing By MiRNA	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation ER-associated Misfolded Protein Catabolic Process
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Macular telangiectasia type 2 ( 33654266) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30578418)
Interacting Genes		7 interacting genes: APP BRCA2 HIPK3 NGLY1 RPP14 STAC TRAF6	25 interacting genes: APP BICRAL FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NPAS2 NSFL1C OPA3 PAX5 PAX6 PROC RAD23A RAD23B SH3BP1 SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC
Entrez ID		8994	55768
HPRD ID		05177	10118
Ensembl ID		ENSG00000144791	ENSG00000151092
Uniprot IDs		Q9UGP4	Q96IV0
PDB IDs			2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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