TRIM15 and MED7

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		TRIM15	MED7
Description		tripartite motif containing 15	mediator complex subunit 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Ubiquitin Ligase Complex Nucleoplasm Transcription Regulator Complex Mediator Complex Nuclear Body
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mesodermal Cell Fate Determination Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Transcription, DNA-templated
Pathways			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494)	Medication use (thyroid preparations) ( 31015401)
Interacting Genes		39 interacting genes: ACD ACTB AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2U VASP VCL VIM YJU2	23 interacting genes: CAB39 CTDP1 DNMT3L ESR1 ESR2 HAUS1 HGS HNF4A IKBKG LZTR1 MED31 MED8 MED9 PCBD2 PML RBFOX2 RELA RHOXF2 SREBF1 TRIM15 TRIM29 UBE2I ZSCAN1
Entrez ID		89870	9443
HPRD ID		15551	05439
Ensembl ID		ENSG00000204610	ENSG00000155868
Uniprot IDs		Q5SRL0 Q9C019	O43513 Q6IAZ5
PDB IDs
Enriched GO Terms of Interacting Partners?
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