BTRC and CENPW

Number of citations of the paper that reports this interaction (PubMedID 29863914)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		BTRC	CENPW
Description		beta-transducin repeat containing E3 ubiquitin protein ligase	centromere protein W
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex	Chromosome, Centromeric Region Kinetochore Nucleoplasm Nucleolus Nuclear Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Response To Organic Cyclic Compound Positive Regulation Of Ubiquitin Protein Ligase Activity	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Chromosome Organization Cell Division Kinetochore Assembly
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation	Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Walking pace ( 33128006)	Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body shape index ( 34021172) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Caffeine consumption from coffee or tea ( 33287642) Coronary artery disease ( 29212778) Cortical surface area (global PC1) ( 32198502) Cortical surface area (visual PC2) ( 32198502) Diastolic blood pressure ( 27841878) Feeling nervous ( 29500382) Food addiction ( 27106561) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172 25673412) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intracranial volume ( 22504418) Intraocular pressure ( 29617998) Kidney volume ( 34128465) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Lung function (FVC) ( 30061609) Male-pattern baldness ( 29146897 27182965 28196072) Menarche (age at onset) ( 27182965 25231870) Monobrow ( 27182965) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Neuroticism ( 29255261) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Pulse pressure ( 27841878) QT interval ( 29213071) Subcortical brain region volumes ( 25607358) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Type 1 diabetes ( 30659077 30572963) Type 2 diabetes ( 30297969 32499647 28869590) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		86 interacting genes: AGO2 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 DPCD E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 IL10RA JUP KDR KMT5A LINC00511 LPCAT1 MCL1 MDM2 MYB MYC NFE2 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PER2 PLK4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA RNF7 SKP1 SLC7A11-AS1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAFAZZIN TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 XRCC1 ZC3H12A	6 interacting genes: BTRC CENPB CENPT CUL1 H3C1 NPM1
Entrez ID		8945	387103
HPRD ID		04596	16660
Ensembl ID		ENSG00000166167	ENSG00000203760
Uniprot IDs		A0A0S2Z4P6 B2R8L3 B7Z3H4 Q68DS0 Q9Y297	A0A0A0MRK5 Q5EE01
PDB IDs		1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU
Enriched GO Terms of Interacting Partners?
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