CCNB1 and UBE3D

Number of citations of the paper that reports this interaction (PubMedID 15749827)
6

Data Source:
BioGRID (enzymatic study)

		CCNB1	UBE3D
Description		cyclin B1	ubiquitin protein ligase E3D
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Centrosome Cytosol Membrane Cyclin B1-CDK1 Complex	Ubiquitin Ligase Complex Nucleus Cytosol
	Molecular Function	Patched Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Ubiquitin-like Protein Ligase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Protein Binding Cyclin Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Oocyte Maturation In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Mitotic Spindle Organization Mitotic Metaphase Plate Congression Spermatogenesis Response To Xenobiotic Stimulus Response To Mechanical Stimulus Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone Phosphorylation Tissue Regeneration Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Protein-containing Complex Assembly Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Histone H3-S10 Phosphorylation Involved In Chromosome Condensation	Protein Polyubiquitination Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		E2F-enabled inhibition of pre-replication complex formation Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Depolymerisation of the Nuclear Lamina TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Mitotic Prophase Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional regulation by RUNX2	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Adult body size ( 32376654) Crohn's disease ( 26891255) Entorhinal cortical volume ( 31530798) Heel bone mineral density ( 30598549 28869591) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189)
Interacting Genes		57 interacting genes: ANAPC11 ARID4A BRCA1 CCNB1IP1 CCNF CDC20 CDC25A CDC25C CDC34 CDC6 CDK1 CDKN1A CDKN1B CDT1 EP300 FLNA FZR1 GADD45A GADD45B GADD45G H1-1 H1-5 HERC5 ITPR1 KAT5 MAP4 MEF2C MOK OGT OTUD7B PBK PCNA PIN1 PKMYT1 PLK1 POLA1 PRC1 PRKDC PRKN PTCH1 PTMA RALBP1 RB1 RPA1 RUNX2 SQSTM1 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 TULP3 UBE2D2 UBE2N UBE3C UBE3D XIAP	3 interacting genes: CCNB1 MAGEA11 UBE2C
Entrez ID		891	90025
HPRD ID		00454	12861
Ensembl ID		ENSG00000134057	ENSG00000118420
Uniprot IDs		P14635	Q4G0J6 Q4G0X5 Q7Z6J8
PDB IDs		2B9R 2JGZ 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4
Enriched GO Terms of Interacting Partners?
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