TAX1BP1 and TSEN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TAX1BP1	TSEN2
Description		Tax1 binding protein 1	tRNA splicing endonuclease subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus Centrosome Cytosol
	Molecular Function	Protein Binding Kinase Binding Metal Ion Binding	TRNA-intron Endonuclease Activity Nucleic Acid Binding Protein Binding Lyase Activity
	Biological Process	Apoptotic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Apoptotic Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling	tRNA processing in the nucleus
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Hypospadias ( 25108383) Metabolite levels ( 23823483)	Body shape index ( 34021172) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Systemic lupus erythematosus ( 28714469) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		76 interacting genes: ARHGAP1 AZI2 C18orf25 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN EMILIN1 FAM161A FAM168A FAM189A2 FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LGALS8 LITAF LMO3 LNX1 LRATD2 MAP1LC3B MAP1LC3C MRPL11 MRPL53 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RB1CC1 RIPK1 RNF11 SCNM1 SERPINB7 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP1 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446	8 interacting genes: CADPS CTAG2 GABPB2 NUP210 RANBP10 TAX1BP1 TEPSIN TSEN54
Entrez ID		8887	80746
HPRD ID		05618	10576
Ensembl ID		ENSG00000106052	ENSG00000154743
Uniprot IDs		B4DSG5 Q86VP1	A0A024R2G3 Q8NCE0
PDB IDs		2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G
Enriched GO Terms of Interacting Partners?
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