ARHGEF7 and NOX1

Number of citations of the paper that reports this interaction (PubMedID 16329988)
7

Data Source:
BioGRID (pull down)

		ARHGEF7	NOX1
Description		Rho guanine nucleotide exchange factor 7	NADPH oxidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Centrosome Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Neuron Projection Neuronal Cell Body Mitotic Spindle Pole Postsynapse	Early Endosome Plasma Membrane Cell Junction Cell Projection NADPH Oxidase Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Gamma-tubulin Binding	Voltage-gated Ion Channel Activity Protein Binding Superoxide-generating NAD(P)H Oxidase Activity Small GTPase Binding Metal Ion Binding NADP Binding
	Biological Process	Golgi Organization Signal Transduction Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of GTP Binding Negative Regulation Of Microtubule Nucleation Positive Regulation Of Lamellipodium Morphogenesis	Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin NADP Metabolic Process Defense Response Inflammatory Response Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Migration Extracellular Matrix Organization Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Respiratory Burst Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Intracellular PH Elevation Cellular Response To Hyperoxia Oxygen Metabolic Process Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Stress Response To Acidic PH
Pathways		EGFR downregulation NRAGE signals death through JNK Ephrin signaling G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle	RHO GTPases Activate NADPH Oxidases CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs			Oxygen
Diseases
GWAS		Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824) Weight ( 34074324)
Interacting Genes		36 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN FXR1 FXR2 GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PRRG4 PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG	5 interacting genes: ARHGEF7 CYBA NOXA1 NOXO1 TBXA2R
Entrez ID		8874	27035
HPRD ID		05688	02203
Ensembl ID		ENSG00000102606	ENSG00000007952
Uniprot IDs		A0A024RDY9 B7Z344 B7Z6G2 E9PDQ5 Q14155 Q5W9H1	A6NGA6 Q1ZYL4 Q9Y5S8
PDB IDs		1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?
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