PER3 and CSNK1E

Number of citations of the paper that reports this interaction (PubMedID 11865049)
90

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PER3	CSNK1E
Description		period circadian regulator 3	casein kinase 1 epsilon
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Binding Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Regulation Of Circadian Sleep/wake Cycle, Sleep Protein Stabilization	DNA Repair Protein Phosphorylation Endocytosis Signal Transduction Wnt Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cellular Protein Localization Positive Regulation Of Wnt-mediated Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Non-canonical Wnt Signaling Pathway
Pathways			WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Circadian Clock Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol AURKA Activation by TPX2
Drugs			Seliciclib
Diseases
GWAS		Chronotype ( 30696823) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Ulcerative colitis ( 28067908)	Keratoconus ( 31855235) Mastocytosis ( 32752121)
Interacting Genes		9 interacting genes: ARNTL CLOCK CRY1 CRY2 CSNK1D CSNK1E PER1 PER2 SP1	55 interacting genes: AKAP9 ANKRD6 APC APP ARHGEF1 ARNTL AXIN1 AXIN2 BBS10 BHLHE41 BID CADM4 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HES1 KAT7 MCC NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRC PTPRD RAD54B RBX1 RORA RORC SOCS3 TAFAZZIN TAOK1 TNS2 TRIM3 WDCP ZMYND8 ZNF227 ZNF618
Entrez ID		8863	1454
HPRD ID		09138	02919
Ensembl ID		ENSG00000049246	ENSG00000213923
Uniprot IDs		A0A087WV69 A2I2N5 P56645	P49674 Q5U045
PDB IDs			4HNI 4HOK
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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