HDAC3 and BRIP1

Number of citations of the paper that reports this interaction (PubMedID 22792074)
25

Data Source:
BioGRID (enzymatic study)

		HDAC3	BRIP1
Description		histone deacetylase 3	BRCA1 interacting helicase 1
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Transcription Repressor Complex Mitotic Spindle	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Transcription Corepressor Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Enzyme Binding Cyclin Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding NF-kappaB Binding DNA-binding Transcription Factor Binding	DNA Binding DNA Helicase Activity Chromatin Binding RNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Chromatin Organization Protein Deacetylation Negative Regulation Of Myotube Differentiation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Spindle Assembly Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Fluid Shear Stress Positive Regulation Of Cold-induced Thermogenesis	DNA Damage Checkpoint Signaling Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Spermatogonial Cell Division Spermatid Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Negative Regulation Of Gene Expression Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination DNA Duplex Unwinding Chiasma Assembly Cellular Response To Vitamin Cellular Response To Hypoxia Seminiferous Tubule Development Cellular Response To Angiotensin Double-strand Break Repair Involved In Meiotic Recombination
Pathways		NR1D1 (REV-ERBA) represses gene expression p75NTR negatively regulates cell cycle via SC1 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Association of TriC/CCT with target proteins during biosynthesis Regulation of lipid metabolism by PPARalpha Circadian Clock Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Heme signaling Heme signaling	Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs		Vorinostat Belinostat Pracinostat Panobinostat Mocetinostat
Diseases
GWAS		Refractive error ( 32231278)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		102 interacting genes: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRIP1 BRMS1 CBFA2T3 CCN5 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 DAXX DHX30 EED ELL EP300 ESR1 EWSR1 GATA1 GATA2 GATA3 GCM1 GPS2 GTF2I GTF2IRD1 H2AC1 H2BC1 H3C1 H4C1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1A HIF1AN HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1T1 RUNX2 RXRA SMYD1 SRC SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL XPO1 YY1 ZBTB16	14 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HPN HSD17B14 MRPS23 PATZ1 PECAM1 RPA1 SIRT1 TOPBP1
Entrez ID		8841	83990
HPRD ID		08950	05797
Ensembl ID		ENSG00000171720	ENSG00000136492
Uniprot IDs		O15379	Q9BX63
PDB IDs		4A69	1T15 1T29 3AL3
Enriched GO Terms of Interacting Partners?
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