SYNGAP1 and ULK2

Number of citations of the paper that reports this interaction (PubMedID 15014045)
79

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		SYNGAP1	ULK2
Description		synaptic Ras GTPase activating protein 1	unc-51 like autophagy activating kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Glutamatergic Synapse	Cytoplasm Cytoplasmic Vesicle Membrane Phagophore Assembly Site Membrane
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Regulation Of GTPase Activity Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Maintenance Of Postsynaptic Specialization Structure	Autophagosome Assembly Autophagy Of Mitochondrion Autophagy Signal Transduction Peptidyl-serine Phosphorylation Piecemeal Microautophagy Of The Nucleus Response To Starvation Late Nucleophagy Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Positive Regulation By Symbiont Of Host Autophagy
Pathways		Regulation of RAS by GAPs
Drugs			Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)
Interacting Genes		29 interacting genes: CAMK2A DLG3 DLG4 DLGAP4 EFHC1 GRIN1 GRIN2B GRIN2D GUCD1 HSF2BP KDR MGAT5B MID2 MKRN3 MPDZ NCK2 NTAQ1 OSTF1 PDGFRB SHANK3 SPAG8 SUOX TLX3 TRIM27 TRIP6 TSSK3 ULK1 ULK2 VENTX	16 interacting genes: ATG14 DIXDC1 DUXAP9 EEF1B2 GABARAP GABARAPL2 LNX1 LUC7L2 NASP POLA2 RAI1 SETDB1 SQSTM1 SYNGAP1 TNPO1 ZNF32
Entrez ID		8831	9706
HPRD ID		16018	10556
Ensembl ID		ENSG00000197283	ENSG00000083290
Uniprot IDs		A0A1U9X8L0 B7ZCA0 Q96PV0	Q8IYT8
PDB IDs			6QAT 6QAU 6QAV 6YID
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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