EED and SMYD3

Number of citations of the paper that reports this interaction (PubMedID 22659877)
84

Data Source:
BioGRID (unspecified method)

		EED	SMYD3
Description		embryonic ectoderm development	SET and MYND domain containing 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol ESC/E(Z) Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	Transcription Corepressor Binding Protein Binding Enzyme Activator Activity Nucleosome Binding Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H3-K27 Specific)	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spinal Cord Development Negative Regulation Of Transcription, DNA-templated Regulation Of Catalytic Activity Histone H3-K27 Methylation	Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Malaria ( 31844061) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Renal underexcretion gout ( 32238385) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)
Interacting Genes		42 interacting genes: AEBP2 ANXA5 AR BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TRIM55 TRIM63 TSC22D1 UBE2W YY1 ZBED8 ZFP42	22 interacting genes: APP CAMK2B CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K SCCPDH SHC3 TRIT1 VANGL1 ZNF557
Entrez ID		8726	64754
HPRD ID		09343	12297
Ensembl ID		ENSG00000074266	ENSG00000185420
Uniprot IDs		E9PJK2 O75530	B3KN46 Q9H7B4
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6SFB 6SFC 6U4Y 6W7F 6W7G 6WKR 7KSO 7KSR 7KTP 7KXT	3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF 6YUH 7BJ1
Enriched GO Terms of Interacting Partners?
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