TRADD and CNTRL

Number of citations of the paper that reports this interaction (PubMedID 10187805)
65

Data Source:
HPRD (in vivo)

		TRADD	CNTRL
Description		TNFRSF1A associated via death domain	centriolin
Image			No pdb structure
GO Annotations	Cellular Component	Tumor Necrosis Factor Receptor Superfamily Complex Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Death-inducing Signaling Complex Receptor Complex Membrane Raft	Centrosome Microtubule Organizing Center Cytosol Membrane Perinuclear Region Of Cytoplasm Flemming Body Meiotic Spindle Pole Mitotic Spindle Pole Centriolar Subdistal Appendage
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Tumor Necrosis Factor Receptor Binding Protein Binding Kinase Binding Identical Protein Binding Protein-containing Complex Binding Death Domain Binding	Protein Binding Cytoskeletal Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Hair Follicle Development Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Kidney Development Ventricular Septum Development Cell Cycle Aorta Development Cell Division Regulation Of Cytoskeleton Organization Coronary Vasculature Development
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Regulation of necroptotic cell death Dimerization of procaspase-8 TNF signaling Defective RIPK1-mediated regulated necrosis	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Pulse pressure ( 27841878)
Interacting Genes		24 interacting genes: APBB2 BCL10 BIRC2 CNTRL DAPK1 FADD FAS HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TMC8 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP	9 interacting genes: CREBBP ENG MAP3K4 MAPK6 PBX3 SPTAN1 TRADD TRAF1 TSC1
Entrez ID		8717	11064
HPRD ID		04610	05691
Ensembl ID		ENSG00000102871	ENSG00000119397
Uniprot IDs		Q15628	B2RP65 Q7Z7A1
PDB IDs		1F2H 1F3V 5XME 6AC0
Enriched GO Terms of Interacting Partners?
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