EIF3A and EIF4B

Number of citations of the paper that reports this interaction (PubMedID 8816444)
64

Data Source:
BioGRID (affinity chromatography technology, far western blotting, affinity chromatography technology)
HPRD (in vitro, in vivo)

		EIF3A	EIF4B
Description		eukaryotic translation initiation factor 3 subunit A	eukaryotic translation initiation factor 4B
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Microtubule Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Dendrite Neuronal Cell Body Postsynapse
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Receptor Tyrosine Kinase Binding	RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translation Reinitiation Translational Initiation Negative Regulation Of ERK1 And ERK2 Cascade IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Keratoconus ( 33649486) Plateletcrit ( 32888494)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)
Interacting Genes		24 interacting genes: BBS1 BBS4 BZW2 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FXR1 LAMTOR5 LINC01554 MTNR1B PAIP1 REL RNF139 SRPK2 TFIP11 TSC1 UBC UPF1 YWHAZ	19 interacting genes: ACD CASP3 CSNK2A1 EIF3A EIF4E IPO13 LAMTOR5 LINC01554 PABPC1 PAK2 POT1 RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11
Entrez ID		8661	1975
HPRD ID		03618	04892
Ensembl ID		ENSG00000107581	ENSG00000063046
Uniprot IDs		Q14152	B4DRM3 E7EX17 P23588 Q7Z5Y0
PDB IDs		3J8B 3J8C 6YBD 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09	1WI8 2J76 6FEC
Enriched GO Terms of Interacting Partners?
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