DYNLL1 and NTRK2

Number of citations of the paper that reports this interaction (PubMedID 11157096)
51

Data Source:
HPRD (in vivo)

		DYNLL1	NTRK2
Description		dynein light chain LC8-type 1	neurotrophic receptor tyrosine kinase 2
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Membrane Dynein Complex Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane Axon Cytoplasm	Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Dendrite Early Endosome Membrane Terminal Bouton Dendritic Spine Receptor Complex Axon Terminus Perinuclear Region Of Cytoplasm
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Nitric-oxide Synthase Regulator Activity Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding	Protease Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity Neurotrophin Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity
	Biological Process	Apoptotic Process Microtubule-based Process Spermatid Development Substantia Nigra Development Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of Nitric Oxide Biosynthetic Process Cilium Assembly	Vasculogenesis Neuron Migration Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Learning Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Neuronal Action Potential Propagation Central Nervous System Neuron Development Cerebral Cortex Development Myelination In Peripheral Nervous System Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Synapse Assembly Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By Neuropeptide, Modulating Synaptic Transmission Negative Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Anoikis
Pathways		Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	NGF-independant TRKA activation BDNF activates NTRK2 (TRKB) signaling NTF3 activates NTRK2 (TRKB) signaling NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5
Drugs			Amitriptyline Esketamine Entrectinib Fostamatinib Larotrectinib
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Birth weight ( 24950379) Body mass index ( 28892062 25760438) Body size at age 10 ( 32376654) Gout (normal type) ( 32238385) Lifetime anxiety disorder ( 31748690) Menarche (age at onset) ( 25231870) Parkinson's disease progression (cognitive) ( 33111402) Refractive error ( 32231278) Serum metabolite concentrations in chronic kidney disease ( 29545352) Type 2 diabetes ( 31118516) Waist-to-hip circumference ratio (recreational physical activity interaction) ( 23192594)
Interacting Genes		112 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C12orf40 C14orf119 C19orf44 CA2 CACNB1 CCDC28A CLIP2 CS DAZ1 DCTN5 DLG4 DLGAP1 DNAJB9 DNAL4 DNM2 DNM3 DNMT1 DPPA3 DYNC1H1 DYNC1I1 EEF1A1 ERG28 FAM117B FAM153A FAM53B GABARAPL1 GABARAPL2 GABRQ GAPDH GLUD1 GLUL GNL3L GPHN GPRIN2 GRIN3A HIP1R HMBOX1 HOMER3 HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MORN3 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 ODF3 OR7C2 OTUD6A PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH PPP3R2 RAB4A RACK1 RASGRP4 RFC5 RGS2 SHROOM3 SLC13A1 SMCP SUDS3 TERT THAP10 THAP8 TNFRSF14 TP53BP1 TRIM54 TSNARE1 TUBA3C TUBB TXNDC17 VIM VSIG10 WSB2 ZHX1 ZMYND11 ZNF354A ZNF710	38 interacting genes: AP1B1 BDNF CDK20 DOK5 DYNLL1 EGFR ERBB2 ERBB4 FRS2 FRS3 FYN GIPC1 KCNS1 KIDINS220 NCK1 NCK2 NDFIP1 NGFR NMNAT1 NTF3 NTF4 NXNL2 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SORT1 SQSTM1 TRAF6 UBB USP8
Entrez ID		8655	4915
HPRD ID		03334	02712
Ensembl ID		ENSG00000088986	ENSG00000148053
Uniprot IDs		P63167 Q6FGH9	A0A024R230 Q16620 Q548C2 Q5VWE5
PDB IDs		1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2	1HCF 1WWB 2MFQ 4ASZ 4AT3 4AT4 4AT5 5MO9
Enriched GO Terms of Interacting Partners?
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