CHRD and F2R

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CHRD	F2R
Description		chordin	coagulation factor II thrombin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Region Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Surface Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane
	Molecular Function	Protein Binding Cytokine Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding
	Biological Process	Skeletal System Development Positive Regulation Of Mesenchymal Cell Proliferation BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion	Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Establishment Of Synaptic Specificity At Neuromuscular Junction Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Platelet Dense Granule Organization Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Negative Regulation Of Renin Secretion Into Blood Stream
Pathways			Common Pathway of Fibrin Clot Formation Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs)
Drugs			Streptokinase SR-123781A Vorapaxar Thrombin
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet count ( 32888494 20139978) Plateletcrit ( 32888494 27863252)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Mean platelet volume ( 22139419) Platelet count ( 22139419) Platelet distribution width ( 27863252)
Interacting Genes		60 interacting genes: ADAMTSL4 ATN1 BMP1 BMP2 CATSPER1 CD36 CHRDL2 CYSRT1 F2R FXR1 FXR2 GATA1 HOXA1 HRG INCA1 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP19-2 KRTAP19-5 KRTAP22-1 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 LCE1C LCE1F LCE5A LIN7A MEOX2 NBPF19 NOTCH2NLA NR0B2 NR4A3 NUFIP2 OTX1 PLSCR1 POU4F2 RGS17 SLC15A2 SMAD3 SPRY1 SPRY2 SPRY3 TLL1 TRIM42 TSPAN4 TWSG1	20 interacting genes: ARRDC3 ATP13A2 CAPN1 CHRD CTSG CXCL14 ELANE F2 F2RL1 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNX1
Entrez ID		8646	2149
HPRD ID		04592	01763
Ensembl ID		ENSG00000090539	ENSG00000181104
Uniprot IDs		E7ESX1 Q8N2W7 Q9H2X0	A0A024RAP7 P25116
PDB IDs			1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7
Enriched GO Terms of Interacting Partners?
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