LY6D and ABCB11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		LY6D	ABCB11
Description		lymphocyte antigen 6 family member D	ATP binding cassette subfamily B member 11
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane	Endosome Plasma Membrane Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Intercellular Canaliculus Intracellular Canaliculus Recycling Endosome Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Bile Acid Transmembrane Transporter Activity Canalicular Bile Acid Transmembrane Transporter Activity ABC-type Bile Acid Transporter Activity ATPase-coupled Transmembrane Transporter Activity
	Biological Process	Cell Adhesion Lymphocyte Differentiation	Fatty Acid Metabolic Process Bile Acid Biosynthetic Process Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Protein Ubiquitination Regulation Of Fatty Acid Beta-oxidation Cholesterol Homeostasis Xenobiotic Transport Xenobiotic Export Transmembrane Transport Lipid Homeostasis Phospholipid Homeostasis Positive Regulation Of Bile Acid Secretion Regulation Of Bile Acid Metabolic Process
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective ABCB11 causes PFIC2 and BRIC2
Drugs			ATP Glyburide
Diseases
GWAS			Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010 33339817) Cholesterol, total ( 24097068) Egg allergy ( 25710614) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 18521185) Gamma glutamyl transferase levels ( 29403010 33339817) Glycated hemoglobin levels ( 24647736 34059833 20858683 31213470 29170429) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolically unhealthy in normal weight ( 33500527) Metabolite levels ( 21909109) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure in sickle cell anemia ( 24058526) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		7 interacting genes: ABCB11 AQP6 ARFIP2 ELOVL4 PKIB TMEM31 TMEM86B	4 interacting genes: DDIT4L HAX1 LY6D NR4A1
Entrez ID		8581	8647
HPRD ID		09370	04436
Ensembl ID		ENSG00000167656	ENSG00000073734
Uniprot IDs		Q14210	O95342
PDB IDs			6LR0
Enriched GO Terms of Interacting Partners?
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