CDC14A and CDC6

Number of citations of the paper that reports this interaction (PubMedID 22117071)
40

Data Source:
BioGRID (enzymatic study)

		CDC14A	CDC6
Description		cell division cycle 14A	cell division cycle 6
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Nuclear Body Stereocilium Tip Kinocilium Mitotic Spindle Kinociliary Basal Body	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding Kinase Binding
	Biological Process	Microtubule Cytoskeleton Organization Cell Cycle Regulation Of Exit From Mitosis Sensory Perception Of Sound Positive Regulation Of Cytokinesis Peptidyl-tyrosine Dephosphorylation Cell Division Cilium Assembly	DNA Replication Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Signaling Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin
Pathways		Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase MAPK6/MAPK4 signaling	Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31015462) Fasting glucose ( 34059833) Fever and diarrhea in mesalamine-treated irritable bowel disease ( 33501934) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009)	Asthma ( 31619474)
Interacting Genes		15 interacting genes: AATK ATPAF2 BRAP C14orf119 CDC25B CDC6 CHRM1 FZR1 KIF20A LMTK2 PLK1 POLR2A PTK7 ROR2 TP53	40 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CCNF CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 DSC2 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC OGT ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBE2K UBR1
Entrez ID		8556	990
HPRD ID		04614	04022
Ensembl ID		ENSG00000079335	ENSG00000094804
Uniprot IDs		A0A0U1RQX7 A0A2R8YDJ8 B4DY86 Q59EF4 Q9UNH5	A0A024R1S2 Q99741
PDB IDs			2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?
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