PIAS1 and PLAG1

Number of citations of the paper that reports this interaction (PubMedID 15208321)
12

Data Source:
BioGRID (pull down)

		PIAS1	PLAG1
Description		protein inhibitor of activated STAT 1	PLAG1 zinc finger
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	Nucleoplasm Centrosome Cytosol Nuclear Speck
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding SUMO Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Visual Learning Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation Protein-DNA Complex Assembly	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gland Morphogenesis Multicellular Organism Growth Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glial Cell Proliferation Prostate Gland Growth
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Haemorrhoidal disease ( 33888516) Major depressive disorder ( 23377640) Number of twin births ( 30760885)	Birth weight ( 31043758) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 25429064 19396169 19343178 19893584 31562340 18391951 20189936) Hip circumference adjusted for BMI ( 34021172 25673412) Monocyte count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		110 interacting genes: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CASP8 CBS CDK4 CEBPA CEBPE CHD3 CHUK CNOT7 CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 EP300 ESR1 ESR2 FANCI FHL3 FLI1 GATA4 GLUL GRM8 GSK3B GTF2IRD1 HECTD2 HIC1 HTT IKZF5 JUN KLF3 L3MBTL2 LSM3 MAML1 MBD1 MDC1 MDM2 MITF MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRPF40A PSME3 PTK2 PTPN1 QKI RAD54L2 RBBP6 RELA RPA2 SATB1 SATB2 SERBP1 SGTA SKIL SMAD1 SMAD4 SMAD7 SNAI2 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO1P1 SUMO2 SUMO3 TBP TERF2 TEX11 TP53 TP73 TRIM27 TRIM5 TRIM55 TRIM63 TSG101 UBE2I UBE2L3 YWHAZ ZBED1 ZNF451 ZNF76	5 interacting genes: KPNA2 PIAS1 PIAS2 PIAS4 SMAD3
Entrez ID		8554	5324
HPRD ID		16029	04321
Ensembl ID		ENSG00000033800	ENSG00000181690
Uniprot IDs		O75925 Q1XBU8	A0A024R7Z0 Q6DJT9
PDB IDs		1V66
Enriched GO Terms of Interacting Partners?
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