MAPKAPK5 and PLA2G4A

Number of citations of the paper that reports this interaction (PubMedID 10978317)
59

Data Source:
HPRD (in vivo, in vitro)

		MAPKAPK5	PLA2G4A
Description		MAPK activated protein kinase 5	phospholipase A2 group IVA
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Golgi Membrane Nucleus Nuclear Envelope Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding O-acyltransferase Activity Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity Phosphatidylinositol-4-phosphate Binding Phosphatidyl Phospholipase B Activity Ceramide 1-phosphate Binding
	Biological Process	MAPK Cascade Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Protein Autophosphorylation Positive Regulation Of Telomerase Activity Cellular Senescence Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomere Capping	Prostaglandin Biosynthetic Process Positive Regulation Of T-helper 1 Type Immune Response Glycerol Metabolic Process Monoacylglycerol Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Positive Regulation Of Platelet Activation Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Catabolic Process Phosphatidylcholine Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Glycerophospholipid Catabolic Process Arachidonic Acid Secretion Cellular Response To Antibiotic
Pathways		Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation	phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonic acid metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic
Drugs		Fostamatinib	Fluticasone propionate Procaine Quinacrine Niflumic acid Darapladib Fluticasone
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Spleen volume ( 34128465) Tea consumption ( 33080986)	Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163) Generalized epilepsy ( 22949513) Hip circumference adjusted for BMI ( 28552196) Hyperinsulinemia in less-fat diet ( 30327367) Hyperinsulinemia x saturated fatty acids interaction ( 30327367) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798) Non-del(5q) myelodysplastic syndromes ( 31738830) Uterine fibroid size (maximum volume) ( 30196971) Zinc levels ( 26025379)
Interacting Genes		30 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HMGB1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SRPK1 SRPK2 TAB1 TP53 ZNF282 ZNF576	24 interacting genes: ANXA2 BORCS6 CAP1 CASP1 CASP3 CASP4 ITGA2B ITGB3 JAK1 KAT5 MAPK1 MAPK14 MAPKAPK5 MKNK1 NCF1 PLA2G5 PRKCA RELA RPS6KA5 SHBG SIRT2 UBXN1 VIM XAGE1B
Entrez ID		8550	5321
HPRD ID		09467	08986
Ensembl ID		ENSG00000089022	ENSG00000116711
Uniprot IDs		Q8IW41	B4DZI4 P47712
PDB IDs			1BCI 1CJY 1RLW
Enriched GO Terms of Interacting Partners?
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